The spindle proteins AURKA, BUB1, and MAD2L1 are important components of the spindle assembly checkpoint (Xue et al., 2016), which has been frequently established as an important mechanism that drives aneuploidy and carcinogenesis in CRC (Chen et al., 1998; Burum-Auensen et al., 2007). The gene discussed is MAD2L1; the disease is colorectal carcinoma.