PRDM16 and posterior cortical atrophy: Transfection with hsa-mir-96 mimic reduced the luciferase activity of the PRDM16 reporter vector, but not the mutated vector, indicating that hsa-mir-96 regulates PRDM16 expression in PCa cells by directly binding to the predicted site in the 3’ UTR of PRDM16 (Figure 6B).