Given that tumor microenvironment (TME) is composed of tumor-associated macrophages (TAM), polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC), monocytic MDSC (M-MDSC), and dendritic cells (DC), and etc., we analyzed the LCN2 expression in the CD11b+, F4/80+, CD11c+, NK1.1+, and CD3+ cells in the tumor of the cancer mice with or without stroke. This evidence concerns the gene LCN2 and neoplasm.