As is discovered, LCN2 can be expressed in various components of the CNS, including neurons, the choroid plexus, microglia, and astrocytes in pathological conditions and serves as a “help-me” signal to activate astrocytes and microglia, facilitating neurovascular recovery after stroke and brain injury and mediating anti-inflammatory effects against sepsis-induced brain damage and behavioral changes (22). Here, LCN2 is linked to Sepsis.