A cluster of CCR4+GATA3+ central memory cells (CD8 #5) expressed low levels of IL-2, which was more frequent in patients with AD than in all other groups (p < 0.0001 vs. HC and HT, p = 0.0009 vs. N-T1D, p = 0.0001 vs. L-T1D, p = 0.004 vs. GD). This evidence concerns the gene CCR4 and Alzheimer disease.