LDLR and atherosclerosis: Intriguingly, the histone demethylase Tet2, which has been identified as a risk of atherosclerosis associated with dysfunctional myelopoiesis and activated NLRP3 inflammasome/IL-1 pathway (65), was found to be epigenetically primed in myeloid progenitors of WD-fed LDLR−/− mice (34), providing additional evidence that WD-induced trained immunity plays a causal role in atherogenesis.