LDLR and atherosclerosis: A recent study using an atherosclerosis mouse model (LDLR−/− mice) showed that the sterile inflammatory Western diet (WD), which has been known as a risk factor of ASCVD, can similarly trigger hematopoietic precursor cell expansion and myelopoiesis associated with long-term transcriptional and epigenetic reprogramming of myeloid progenitor cells (34).