Patients Breast cancer patients (110)  Neuroblastoma patients (111)  CLL patients (high HLA-E expression) (112)  Head and neck, Squamous cell carcinoma, colorectal carcinoma (46)Animal models B/T-cell lymphoma murine models (46)In-vitrostudies Upregulation following cytokine induction (NKs from multiple myeloma patients) (113)  Erythroleukemia, B-cell lymphoma, head and neck, squamous cell carcinoma, ovarian tumor cell lines (46). The gene discussed is HLA-E; the disease is breast cancer.