These duplexes can be tested further in various mouse models of diseases involving MASP-1 and MASP-2 such as IgA Nephropathy (77) and experimental pneumococcal meningitis (78) to understand the contribution of liver MASP1 and MASP2 to disease pathology in conditions where LP activations has been implicated. Here, MASP1 is linked to pneumococcal meningitis.