To examine the systemic effect of GalNAc-MASP-1-siRNA and GalNAc-MASP-2-siRNA on arthritis, mice were injected (s.q.)three times with GalNAc-Luciferase, GalNAc-MASP-1-siRNA, or GalNAc-MASP-2 siRNA before the induction of disease. This evidence concerns the gene MASP1 and arthritic joint disease.