MASP2 and pneumococcal meningitis: These duplexes can be tested further in various mouse models of diseases involving MASP-1 and MASP-2 such as IgA Nephropathy (77) and experimental pneumococcal meningitis (78) to understand the contribution of liver MASP1 and MASP2 to disease pathology in conditions where LP activations has been implicated.