In another study, capsaicin-induced TRPV1+ fibers-denervation ameliorated the intestinal inflammation in the T-cell-transfer colitis model (118), but the suppressive effect of noxious-dose capsaicin pretreatment only existed in 7–8 weeks old mice for several weeks after T-cell transfer, and these mice eventually developed colitis (128). The gene discussed is TRPV1; the disease is colitis.