GCG and obesity due to melanocortin 4 receptor deficiency: The anti-inflammatory process is associated with lower intestinal permeability in diet-induced obesity mice via improving the tight-junction integrity (Cani et al., 2008), and it has been confirmed that this process might control and increase the production of endogenous GLP-2 in Leptinob/ob mice (Cani et al., 2009).