As shown in Figure 4C, the expression of ZO-1 and occludin repressed by ZIKV infection could be notably rescued only by MG132, a proteasome inhibitor, but not by either BFA, an inhibitor for both V-ATPase-dependent acidification and autophagosome-lysosome fusion or CQ, an inhibitor for fusion of autophagosomes and lysosomes. This evidence concerns the gene TJP1 and Zika virus infectious disease.