Although previous studies have indicated that MRI of LCH in the hypothalamic-pituitary region showed no specific pattern, homogeneous enhancement was usually obvious (20, 21); (3) Extrasellar lesions, especially nodules in the bone, would be suggestive; (4) Tumor markers such as AFP and β-HCG are in the normal range or slightly elevated. This evidence concerns the gene AFP and Langerhans cell histiocytosis.