Among men, after adjusting for alcohol consumption status, smoking status, duration of diabetes, hypertension, dyslipidemia, BMI, HbA1c, eGFR, and the usage of aspirin, losartan, and irbesartan, compared with the first quartile, participants in the fourth quartile of TT and FSH had odds of hyperuricemia that were significantly decreased by 48% (OR 0.52, 95% CI 0.35, and 0.77) and 34% (OR 0.66, 95% CI 0.45, and 0.95) (both P < 0.05). This evidence concerns the gene BRD2 and metabolic syndrome.