Our previous study, referred to as the Survey on Prevalence in East China for Metabolic Disease and Risk Factors (SPECT-China), reported that higher UA levels were associated with lower total testosterone (TT) and sex hormone-binding globulin (SHBG) levels in a total of 1,365 general men (age 55.5 ± 10.8 years) (11). This evidence concerns the gene SHBG and metabolic disease.