Wurth et al. identified, by immunofluorescence, the expression of SOX2, OCT4, NESTIN, and CD133, in seven human GHoma, and five NFPA samples, while NANOG and NOTCH1 were detected in 25 and 50%, respectively, of the samples analyzed; these markers restricted to subsets of cells diffuse within tumor mass, but, in GHomas, do not co-localized with GH-secreting cells (77). This evidence concerns the gene SOX2 and neoplasm.