Moreover, overexpression of HIPPO pathway components (i.e., large tumor suppressor homolog 2, LATS2, and TEAD4), has been described in PA SP cells (73) as well as in poorly differentiated pituitary tumors (null-cell PAs, adamantinous and papillary craniopharyngiomas) which display enhanced YAP/TAZ activity (108). This evidence concerns the gene LATS2 and pituitary tumor.