CD68 and diabetes mellitus: This was accompanied by an overall increase in LV CD68+ stained macrophages with diabetes (P = 0.012), an increase at 12 weeks, and a tendency to be increased at both 8 and 16 weeks of diabetes on post hoc analysis (P = 0.07 and P = 0.06, respectively), as measured by immunohistochemistry (Figures 4D,E).