At the same time, we found that TA-8 significantly inhibited the mRNA expression of COX2 (Figure 5A), iNOS (Figure 5B), VCAM (Figure 5C), IL-1 (Figure 5D), IL-1 (Figure 5E), IL-10 (Figure 5F), IL-6 (Figure 5G), IP-10 (Figure 5H), RANTES (Figure 5I), CCL2 (Figure 5J), HMGB1 (Figure 5K), and TNF-α (Figure 5L) in liver tissue during the period of MODS in sepsis. The gene discussed is HMGB1; the disease is Sepsis.