Inhibition of chemokine production could reduce cerebral edema and reduce cerebral infarction volume (Maria et al., 2012).We found that BZP significantly decreased the expression of NF-κB, TNF-α, IL-6, and ICAM-1 after ischemic stroke in rats and in PC12 cells subjected to hypoxic injury induced by Na2S2O4, suggesting that BZP might inhibit the production of 15-HETE, a metabolite of 15-LOX-2. This evidence concerns the gene NFKB1 and edema.