489TT/HHV-6A positive women also showed higher levels of IL-1β, IL-1α, and IL-8 (CXCL8) suggesting that the 489TT gain-of-function variant not only favors virus entry but also triggers a wide inflammatory response that might contribute to female infertility (Tsimis et al., 2017). This evidence concerns the gene IL1B and female infertility.