S1PR1 and Parkinson disease: Emerging evidence have established that Fingolimod (FTY720), a non-selective sphingosine-1-phosphate receptors (S1PRs) modulator approved for the treatment of multiple sclerosis, can provide significant protection in mouse models of neurodegenerative conditions including two recent studies on PD (Aytan et al., 2016; Zhao et al., 2017).