The studies reported that the activation of the NLRP3 inflammasome leads to the development and release of inflammatory cytokines IL-1β and IL-18, suggesting the role for the NLRP3 inflammasome in the initiation and development of cerebral ischemia (Rathinam et al., 2012; Gao et al., 2017). This evidence concerns the gene IL1B and brain ischemia.