To bridge these research gaps, this study aimed to explore the impact of recipient and donor CASP1, CRP, IL1B, IL2, IL6, IL6R, IL10, MYD88, TGFB, TLR2, TLR4, and TNF genotypes on BPAR incidence in a cohort of predominantly Caucasian kidney transplant recipients treated with TAC as the only CNI (Hu et al., 2018; Hu et al., 2019a; Hu et al., 2019b). The gene discussed is TLR4; the disease is medical procedure.