In addition to CFTR modulators, progress has been made in developing cell-based (Barical et al., 2019; Hayes et al., 2019) and gene-based therapies (Donnelley and Parsons, 2018; Duncan et al., 2018; Lopes-Pacheco et al., 2018; Osman et al., 2018) for CF lung disease. This evidence concerns the gene CFTR and lung disorder.