In clinical neuropathies, granzymes have been labeled in the peripheral nerves (Noguchi et al., 2005; Ni Mhaolcatha et al., 2019), and granzyme B positive lymphocytes are seen in close apposition to neurons in the DRG in the late-stages of Guillain-Barré syndrome (GBS) in which axon degeneration is observed (Wanschitz et al., 2003). This evidence concerns the gene GZMB and Guillain-Barre syndrome.