Piezo1 was activated by Yoda1 that is an effective activator of Piezo1 channel (Syeda et al. 2015), and highly expressed Piezo1 in HCT-116 and SW-480 cells was in negative association with cell viability; however, silencing Piezo1 suppressed colon cancer cell viability. The gene discussed is PIEZO1; the disease is malignant colon neoplasm.