Since there are some reports that GPC-1 is reported to be shed into the extracellular matrix, and high GPC-1-expression tumours secrete a lot of GPC-1 and lead to high serum GPC-1 level,21,26 we might predict an effect of GPC-1-ADC by measuring the serum GPC-1 levels. This evidence concerns the gene GPC1 and neoplasm.