Of note, the association of the NFKB2rs11574851T allele with an increased risk of RA in ACPA-positive subjects remained significant even after correction for multiple testing and was further confirmed in an ACPA-stratified haplotype analysis that showed that the presence of the NFKB2rs11574851T allele was driving the effect of the NFKB2TA haplotype on the risk of RA in ACPA positive subjects but not in ACPA-negative individuals. Here, PRTN3 is linked to rheumatoid arthritis.