Considering the aspects detailed above, but also previous studies suggesting that the NFKB- and NLRP3-inflammasome pathways are genetically determined19, we decided to conduct a case-control study to investigate whether 28 single nucleotide polymorphisms (SNPs) within the NFKB1, NFKB2, NFKBIB, IKBKB, GBP6, IRF4, NLRP3, REL, RELA, KLRC1, KLRK1 | KLRC4, LOC105376246 (ncRNA), TLR4, TLR5, TLR9, TLR10 and TRAF1 | C5 genes influence the risk of developing RA and the response to TNF inhibitors (TNFi). This evidence concerns the gene NFKB2 and rheumatoid arthritis.