Most importantly, an ACPA-stratified meta-analysis of our data with those from the DANBIO registry also revealed that each copy of the NFKB2rs11574851T allele conferred an additive risk of developing RA in ACPA-positive subjects (ORMeta = 1.48, 95%CI 1.18–1.86, P = 0.0006) that was not detected in ACPA-negative individuals (Table 4 and Fig. 1). Here, PRTN3 is linked to rheumatoid arthritis.