Interestingly, the ACPA-stratified haplotype analysis including both the discovery and DANBIO cohorts also confirmed that ACPA-positive subjects carrying the NFKB2TT haplotype (including the NFKB2rs11574851T risk allele) had a significantly increased risk of RA (ORHaplotype-ACPA+ = 1.39, 95%CI 1.11–1.74, P = 0.0042) whereas no effect was detected in ACPA-negative individuals (ORHaplotype-ACPA− = 1.04, 95%CI 0.75–1.44, P = 0.82; Table 5). Here, PRTN3 is linked to rheumatoid arthritis.