Although the complexity of inflammatory pathways implicated in RA development and progression remains in part unknown, there are convincing evidences supporting the view that NFKB pathway and its connection with the NLRP3-inflammasome plays a pivotal role in the modulation of the expression of multiple inflammatory genes implicated in RA development3 and drug response or disease progression4. This evidence concerns the gene NFKB1 and rheumatoid arthritis.