Interestingly, an ACPA-stratified analysis revealed that ACPA-positive subjects carrying the NFKB1rs4648110A/A genotype or the NFKB2rs11574851T allele had a significantly increased risk of developing RA whereas a non-significant effect was found in ACPA-negative patients (ORRec-ACPA+ = 1.65, 95%CI 1.04–2.63, P = 0.031 vs. ORRec-ACPA− = 0.86, 95%CI 0.39–1.90, P = 0.90 and per-allele ORACPA+ = 1.39, 95%CI 1.06–1.83, P = 0.017 and per-allele ORACPA− = 1.02, 95%CI 0.68–1.52, P = 0.93; Table 3). This evidence concerns the gene PRTN3 and rheumatoid arthritis.