NFKB2 and rheumatoid arthritis: On the basis of the effect found for the NFKB2rs11574851 or NFKB2rs12769316 SNPs on the risk of developing RA, we decided to analyse whether these SNPs might exert their biological function directly through the modulation of NFKB2-mediated immune responses or indirectly through the regulation of steroid hormone levels.