BIRC5 and neoplasm: The data reported in Fig. 3a show that viral replication of Survivin_oHSV was, in general, less efficient, compared to the wild-type virus R-LM55; however, Survivin_oHSV replicated to a higher extent in tumour cell lines (SKOV3, SAN and A375) compared to MRC5, with the highest yield in SKOV3 cells, in agreement with the reporter assay data for the Survivin/BIRC5 promoter (Fig. 1a).