Based on the lower strength enrichments in tumour vs. normal tissues (Supplementary Fig. 1) and on reporter analysis (Fig. 1a), we excluded CXCR4. In contrast, TERT and Survivin/BIRC5 promoters appeared more selective for tumour tissue expression and showed the best relative increases in reporter activity in the tumour cell lines. The gene discussed is TERT; the disease is neoplasm.