To evaluate the tumour-restricted replication of the novel virus, SKOV3 (ERBB2+, Survivin promoter permissive) and MRC5 (ERBB2+/−, Survivin promoter non-permissive) cells were infected with one of the following viruses: the wild-type R-LM55, the replication conditional Survivin_oHSV, the ERBB2-retargeted R-LM11314 and the combined SurE_oHSV viruses (see Table 2 for description of the viruses). This evidence concerns the gene ERBB2 and neoplasm.