PYCARD and cancer: Basal expression of ASC appears to be regulated by the Ets family member GA-binding protein α (GABPα), which is enriched at a DNase I hypersensitive site (HS2) intronic element in the ASC promoter.60 Given the important role that ASC plays in inflammasome activation and, in some cases, apoptotic cell death, a better understanding of its regulation may provide insight into how cancers and autoinflammatory diseases progress.