Alternatively, the silencing of PTPN14 in metastatic breast cancer cells that express [MDA-MB-231(shC)] or not CAV1 [MDA-MB-231(shCAV1)] using an esiRNA against PTPN14 (Supplementary Fig. 1b) increased cell migration (Fig. 3g), as well as invasion of those MDA-MB-231 cells expressing CAV1 (Fig. 3h). Here, CAV1 is linked to breast cancer.