VIM and leukemia: In direct support of our observations, vimentin has also been shown to bind and stabilize specific mRNAs including collagen α1 (I) and α2 (I) mRNA in fibroblasts, osteoblastic alkaline phosphatase mRNA in endothelial cells, the opioid receptor mRNA in neuroblastoma cells, or the heme-regulated inhibitor mRNA in leukemia cells [51, 67–69], though the precise mechanisms involved in these posttranscriptional regulations remain unclear.