TF and neoplasm: Notwithstanding the implication of TF-bearing tumor-derived microparticles in hypercoagulability, a local activation of coagulation is more particularly considered to contribute to the creation of a pericellular fibrin/platelet-rich cocoon protecting CTCs against shear stress, anoikis and immune attack and also providing a favorable niche for their early metastatic seeding [10, 12, 13, 17, 30, 32].