When cultured in CCM, significant differences between the MSC gene expression depending on tissue sources were indicated for TWIST, IL6, PDL1, COX2, TGFB1, HGF, BDNF, ICAM and VCAM. The expression of transcription factor TWIST was significantly higher in BM-MSCs compared to AT-MSCs. The gene discussed is TWIST1; the disease is cerebral cavernous malformation.