CREB activity has also been shown to be regulated by PI-3K/Akt signaling in Jurkat T leukemia cells treated with tumor necrosis factor-related apoptosis-inducing ligand64 and tyrosine kinase B/PI-3K/Akt pathway in SH-SY5Y cells treated with brain-derived neurotrophic factor65. The gene discussed is CREB1; the disease is leukemia.