Recently, it has been shown that in ApoE gene-knockout mice with abdominal aortic aneurysms, infusion of ANG II for 4 weeks increased expression of class I HDAC1, 2, and 3, as well as expression of class II HDAC 4 and 7; it also decreased acetylation levels of H3-K1873. The gene discussed is APOE; the disease is abdominal aortic aneurysm.