APOE and Alzheimer disease: In order to investigate the effects of APOE4 expression in an untargeted manner, we performed a transcriptomics analysis on RNA extracted from a brain region that is acutely vulnerable to AD pathology (the EC) vs. a less vulnerable brain region (the PVC) of 14–15 month-old APOE targeted replacement mice (10 APOE3/3 and 19 APOE3/4 males).