In order to determine whether TIGIT might be able to actively promote T-cell exhaustion, we infected WT mice with an intermediate dose of LCMV clone 13 (1 × 105 FFU), which results in an acute infection that is cleared within 10 days and treated them with either an agonistic anti-TIGIT antibody (1G9) or IgG1 isotype control. The gene discussed is TIGIT; the disease is infection.