As previously demonstrated, 1% O2-induced hypoxia significantly increased, while lncRNA RAET1K silencing decreased lactate concentration, glucose uptake, and the protein levels of LDHA and increased the phosphorylation of AMPK, while under 1% O2-induced hypoxia, miR-100-5p inhibition significantly reversed the effects of lncRNA RAET1K silencing on glycolysis and AMPK phosphorylation in HCC cells (Fig. 5a, b, d, e). Here, RAET1K is linked to hepatocellular carcinoma.