Regarding the molecular mechanism, lncRNA RAET1K silencing significantly inhibited while miR-100-5p inhibition enhanced hypoxia-induced increases in lactate concentration and glucose uptake; more importantly, miR-100-5p suppression significantly attenuated the effects of lncRNA RAET1K silencing on hypoxia-induced glycolysis in HCC cells, indicating that the lncRNA RAET1K/miR-100-5p axis might affect HCC cell phenotypes by modulating hypoxia-induced glycolysis in HCC cells. This evidence concerns the gene RAET1K and hepatocellular carcinoma.