When compared to stable infants, significantly lower CXCL8-producing CD4 T cells were seen in infants with clinically suspected sepsis3 (n = 16, p = 0.007) and in those infants with microbiologically confirmed sepsis caused by either coagulase CoNS (n = 9, p = 0.039) or other bacteria (n = 4, p = 0.0007) such as Group B streptococcus, Escherichia coli or Streptococcus anginosus. Here, CD4 is linked to Sepsis.