In human cancer, depletion of TNFAIP8 has been shown to increase the expression of genes associated with anti-proliferation and apoptosis (IL-24, FAT3, LPHN2, EPHA3), fatty-acid oxidation (ACADL), and decrease the expression of several oncogenes such as NFAT5, MALAT1, MET, FOXA1, KRAS, S100P, OSTF15. The gene discussed is TNFAIP8; the disease is cancer.