As miR-422a inhibits the proliferation of osteosarcoma cells by targeting BCL2L2 and KRAS25, miR-148a promotes cancer cell growth in osteosarcoma by targeting phosphatase and tensin homolog (PTEN)26 and miR-133a inhibits osteosarcoma progression by targeting Bcl-xL and Mcl-127. This evidence concerns the gene PTEN and cancer.