For further understanding a role for this pathway in glucose metabolism-related diseases, we noted a recent study that showed a strong association of transcriptional down-regulation of DBC1 and up-regulation of HDAC3 mRNA in peripheral blood mononuclear cells (PBMCs) of Type 2 diabetes patients (33) without providing any mechanistic insight. This evidence concerns the gene HDAC3 and type 2 diabetes mellitus.