PRSS56 and microphthalmia: We, and others, have previously demonstrated that mutations in the gene coding for the secreted serine protease PRSS56 result in a reduction in ocular axial length (nanophthalmos) in humans, and many of these individuals go on to develop angle-closure glaucoma (ACG) (Nair et al., 2011; Gal et al., 2011; Orr et al., 2011).