However, bacterial factors essential for adhesion and invasion, such as the Salmonella invasion proteins SipA and SipC (Ibarra and Steele-Mortimer, 2009) or the mycobacterial Heparin-binding hemagglutinin (HbhA) (Forrellad et al., 2013), were cleaved very efficiently, pointing again toward a defect early during infection in response to GzmB. This evidence concerns the gene PROS1 and infection.