Guillaume et al., 2018 performed an EWAS in neonates and report an association between DNAm at this gene and FA in the left ventrolateral thalamus (Guillaume et al., 2018). Chen et al., 2018 reported differential methylation and discordance in twin pairs discordant for ADHD diagnosis, and identified six probes associated with the SMOC2 gene which were differentially methylated and were associated with differences in striatum (among 48 probes that were differentially methylated with regard to striatum volume) (Chen et al., 2018). SMOC2 encodes SPARC-related modular calcium binding protein 2. The gene discussed is SMOC2; the disease is attention deficit-hyperactivity disorder.