Ziegler et al., 2015 targeted exon 3 of the OXTR gene due to previous work demonstrating an association between methylation in this region and social cognition (Unternaehrer et al., 2012; Ziegler et al., 2015). Puglia et al., 2015 targeted a single CpG site at position -934 relative to the transcription start site, where methylation had previously been associated with autism spectrum disorder (Gregory et al., 2009; Puglia et al., 2015). The gene discussed is OXTR; the disease is autism spectrum disorder.