While BRD4 and BRD2 peaks as well as H3K27ac peaks overlapped MITF-binding sites at the majority of these representative genes, in both normal human melanocytes and melanoma cells, there were some MITF sites such as within the DCT, PIAS3, SLC45A2, and IRF4 loci where BRD4 binding was observed in SK-MEL-5 melanoma cells but not normal human melanocytes (Additional file 7: Fig. S5). The gene discussed is PIAS3; the disease is melanoma.