Interrogation of a larger list of pigment-related genes (379 eGenes) [38] (including both positive and negative regulators of pigmentation) showed a similar trend with the expression of almost 50% of eGenes being differentially regulated as a result of BET inhibition in Melb-a cells and 20–30% of eGenes in melanoma cells (Additional file 4: Table S1). The gene discussed is DNER; the disease is melanoma.