MAPT and Alzheimer disease: As network failure may occur before amyloid-β accumulation [20], SCD has variable association with amyloidopathy and tauopathy [11–18], and detection of aberrant amyloid-β and tau may precede observable structural decline [99], we speculate that our model could fit in-between the Cascading Network Failure [20] and Pathological Cascade [99] models of AD for older adults with SCD that develop AD specifically.