Significantly different expressions between pediatric sepsis patients and controls were validated by qPCR for the 4 lncRNAs (lncRNA lnc-RP11-1220 K2.2.1–7, lncRNA lnc-ANXA3–2, lncRNA lnc-TRAPPC5–1, lncRNA lnc-ZNF638–1) and 4 co-expressed mRNAs (CXCR1, CLEC4D, DYSF, HLX), validating the microarray results. The gene discussed is ZNF638; the disease is Sepsis.