PTEN and cancer: Several reports have suggested that miR-361 plays a critical role in repressing tumor progression by targeting multiple components of many essential signaling pathways implicated in tumor growth, EMT, metastasis, drug resistance, glycolysis, angiogenesis, and inflammation, such as the PTEN/PI3K/AKT, Wnt/β-catenin, EMT/cancer stem cell-related pathways, and VEGF pathway [27].