POU5F1 and cancer: In addition, the expression of two cancer stem cell-related genes (Oct-4 and SOX-2) was elevated in cervical cancer tissues compared with normal tissues [48,49], and their expression was significantly upregulated in HSP90-overexpressing cervical cancer cells (Supplemental Figure S1B), suggesting that loss of miR-361 expression elevates HSP90 levels, and causally increases the expression of Twist1, MCL-1, Oct-4, and SOX-2, leading to the acquisition of EMT phenotypes of cervical cancer cells.