From the literature review and the present results, we can conclude that FoxA1 acts as tumor suppressor gene in CCA via inhibition of cancer cell proliferation and invasion activities and down-regulation of FoxA1 in CCA may subsequently reduce miR-122 expression and induce EMT process leading to intrahepatic CCA progression with poor prognosis. The gene discussed is FOXA1; the disease is cholangiocarcinoma.