The hypoxia experienced in the tumor induced by the uncontrolled growth of tumor cells, induce the secretion of angiogenesis signals, such as vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), angiopoietins or IL-8, to assure oxygen and nutrient supply [136,137]. This evidence concerns the gene VEGFA and neoplasm.