HIF1A and neoplasm: For example, Glass and colleagues [25] identified differences in two TNBC models: reduction of tumor volume through training showed reduced expression of Hif-1α and no change in Glut-1 expression in EO771 cells, however, in transgenic animals (C3 (1) SV40 Tag p16-luc) the training caused an increase in Hif-1α and a reduction in Glut-1 expression, with a consequent increase in tumor size.