MiT RCC is a genetic fusion gene-associated malignant tumor caused by uncontrolled overexpression of MiT factors, followed by translocation with several partner genes, such as PRCC-TFE3 [t (X:1) (p11.2; q21.2)], ASPSCR1-TFE3, SFPQ-TFE3, and NONO-TFE3 fusion genes, and so on. The gene discussed is TFE3; the disease is cancer.