Several studies, including a study published by Stenman et al., showed that even in RET-associated Pheos, using the “Pheochromocytoma of the Adrenal Gland Scaled Score “(PASS) and “Grading System for Adrenal Pheochromocytoma and Paraganglioma” (GAPP) algorithms, the malignancy was over-diagnosed [60]. This evidence concerns the gene RET and hereditary pheochromocytoma-paraganglioma.